P-28: Effects of Resveratrol on Nicotine Toxicity of The Spermatogenesis of Rats

Background: Nicotine is a major toxic component of cigarette smoke and it is a major risk factor in the development of functional disorder of several organ systems. Resveratrol (trans-3,5,4&#039;-trihydroxystilbene; RES) is a naturally occurring polyphenol synthesized by a variety of plant species in response to injury, UV irradiation and fungal attack. It is present in grapes, berries, peanuts. The aim of present study was to determine resveratrol effect on Nicotine Toxicity of the Spermatogenesis of Rats. Materials and Methods: Fifty mature rats of Wistar race were divided into 5 groups of ten as experimental and control groups. Resveratrol and nicotine were given to 50 rats for a period of 28 days. The rats were weighted and after anesthesia, their epididim was taken out and tissue dissections were obtained. Data was analyzed by one-way ANOVA and p<0.05 was considered significant. Results: The showed data in nicotine intoxicated group showed significant and decrease in sperm motility. In contrast, resveratrol significantly improved sperm motility in groups the nicotine. Conclusion: The findings refers that resveratrol can significantly improve the spermatogenesis process in rats and is suggested that suggest its potential properties to reduce the side effects of nicotine in humans.